MAP3K1

GENE INFORMATION

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Gene name

MAP3K1 (HGNC Symbol)

Synonyms

MAPKKK1, MEKK, MEKK1

Description

mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

Chromosome

5 (Chromosome progress)

Cytoband

q11.2

Chromosome location (bp)

56111401 - 56191979

Ensembl

ENSG00000095015 (version 73.37)

Entrez gene

4214

UniProt

Q13233 (UniProt - Evidence at protein level)

neXtProt

NX_Q13233

Antibodypedia

MAP3K1 antibodies
 

PROTEIN VIEW

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MAP3K1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP3K1-001 ENSP00000382423
ENST00000399503
Q13233
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