NANS

GENE INFORMATION

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Gene name

NANS (HGNC Symbol)

Synonyms

SAS

Description

N-acetylneuraminic acid synthase (HGNC Symbol)

Entrez gene summary

This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q22.33

Chromosome location (bp)

100819021 - 100845357

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000095380 (version 75.37)

Entrez gene

54187

UniProt

Q9NR45 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NR45

Antibodypedia

NANS antibodies
 

PROTEIN VIEW

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NANS-001
 
NANS-002
 
NANS-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NANS-001 ENSP00000210444
ENST00000210444
Q9NR45
Show all »
Show » Show » 359 40.3 No 0
NANS-002 ENSP00000404642
ENST00000427646
Q5TBR0
Show all »
Show » Show » 115 12.4 No 0
NANS-006 ENSP00000404107
ENST00000415280
Q5TBR1
Show all »
Show » Show » 140 15.4 No 0