BLNK

GENE INFORMATION

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Gene name

BLNK (HGNC Symbol)

Synonyms

BASH, bca, BLNK-s, Ly57, SLP-65, SLP65

Description

B-cell linker (HGNC Symbol)

Entrez gene summary

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

10 (Chromosome progress)

Cytoband

q24.1

Chromosome location (bp)

97951458 - 98031344

Ensembl

ENSG00000095585 (version 73.37)

Entrez gene

29760

UniProt

Q8WV28 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WV28

Antibodypedia

BLNK antibodies
 

PROTEIN VIEW

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BLNK-001
 
BLNK-002
 
BLNK-003
 
BLNK-004
 
BLNK-201
 
BLNK-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BLNK-001 ENSP00000224337
ENST00000224337
Q8WV28
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Show » Show » 456 50.5 No 0
BLNK-002 ENSP00000360218
ENST00000371176
Q8WV28
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Show » Show » 433 48.2 No 0
BLNK-003 ENSP00000465741
ENST00000495266
K7EKR2
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65 7.4 No 0
BLNK-004 ENSP00000466331
ENST00000467799
Q2MD47
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121 13.8 No 0
BLNK-201 ENSP00000397487
ENST00000413476
Q8WV28
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Show » 404 44.5 No 0
BLNK-202 ENSP00000391924
ENST00000427367
F5GXS1
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421 46.5 No 0