FKBP5

GENE INFORMATION

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Gene name

FKBP5 (HGNC Symbol)

Synonyms

FKBP51, FKBP54, P54, PPIase, Ptg-10

Description

FK506 binding protein 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Chromosome

6 (Chromosome progress)

Cytoband

p21.31

Chromosome location (bp)

35541362 - 35696360

Ensembl

ENSG00000096060 (version 73.37)

Entrez gene

2289

UniProt

Q13451 (UniProt - Evidence at protein level)

neXtProt

NX_Q13451

Antibodypedia

FKBP5 antibodies
 

PROTEIN VIEW

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FKBP5-001
 
FKBP5-201
 
FKBP5-202
 
FKBP5-203
 
FKBP5-204
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FKBP5-001 ENSP00000349811
ENST00000357266
Q13451
Show all »
Show » Show » 457 51.2 No 0
FKBP5-201 ENSP00000444810
ENST00000536438
Q13451
Show all »
Show » Show » 457 51.2 No 0
FKBP5-202 ENSP00000441205
ENST00000539068
Q13451
Show all »
Show » Show » 457 51.2 No 0
FKBP5-203 ENSP00000445412
ENST00000540787
B7Z7Z8
Show all »
Show » 278 31.6 No 0
FKBP5-204 ENSP00000442340
ENST00000542713
Q13451
Show all »
Show » Show » 268 30 No 0