The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Moderate to strong cytoplasmic positivity was observed in thyroid cancers. Several cases of ovarian, enodmetrial and skin cancers along with a few cases of cervical, lung, pancreatic and liver cancers exhibited moderate staining. Remaining tumors were weakly stained or negative.
Malignant cells showed weak to moderate cytoplasmic positivity in most cases. Pancreatic cancers along with a majority of malignant gliomas, malignant lymphomas, squamous cell carcinomas and urothelial cancers were negative. Cases of renal cancers exhibited strong immunoreactivity.
Validation
Two (or more) antibodies yielding similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Two (or more) antibodies yielding similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
