MRPS18A

GENE INFORMATION

? »

Gene name

MRPS18A (HGNC Symbol)

Synonyms

FLJ10548, MRPS18-3

Description

mitochondrial ribosomal protein S18A (HGNC Symbol)

Entrez gene summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

Chromosome

6 (Chromosome progress)

Cytoband

p21.1

Chromosome location (bp)

43639040 - 43655528

Ensembl

ENSG00000096080 (version 73.37)

Entrez gene

55168

UniProt

Q9NVS2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NVS2

Antibodypedia

MRPS18A antibodies
 

PROTEIN VIEW

? »
 
 
 
MRPS18A-001
 
MRPS18A-002
 
MRPS18A-003
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MRPS18A-001 ENSP00000361188
ENST00000372116
Q9NVS2
Show all »
Show » Show » 127 14 No 0
MRPS18A-002 ENSP00000398679
ENST00000427312
Q5QPA5
Show all »
Show » 264 29.7 No 0
MRPS18A-003 ENSP00000361206
ENST00000372133
Q9NVS2
Show all »
Show » Show » 196 22.2 No 0