PGC

GENERAL INFORMATION

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Gene name

PGC

Gene description

Progastricsin (pepsinogen C)

Protein class

Cancer-related genes
Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (stomach)
GTEx:Tissue enriched (stomach)

Protein evidence

Evidence at protein level

Protein localization

Distinct cytoplasmic expression in gastric glands.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA031717 , HPA031718
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (stomach)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (stomach)

Organ

Expression



GENE INFORMATION

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Gene name

PGC

Synonyms

Description

Progastricsin (pepsinogen C) (HGNC Symbol)

Entrez gene summary

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

Chromosome

6

Cytoband

p21.1

Chromosome location (bp)

41736711 - 41754109

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000096088 (version 78.38)

Entrez gene

5225

UniProt

P20142 (UniProt - Evidence at protein level)

neXtProt

NX_P20142

Antibodypedia

PGC antibodies


PROTEIN BROWSER

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ENST00000356667
 
ENST00000373025
 
ENST00000415707
 
ENST00000425343
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PGC-001 ENSP00000362116
ENST00000373025
P20142
Show all »
Show » Show » 388 42.4 Yes 0
PGC-003 ENSP00000349094
ENST00000356667
Q4VXA6
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Show » Show » 140 15.7 Yes 0
PGC-004 ENSP00000399429
ENST00000415707
A2A3L9
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Show » Show » 86 10 No 0
PGC-201 ENSP00000405094
ENST00000425343
P20142
Show all »
Show » Show » 315 34.2 Yes 0