PGC

GENE INFORMATION

? »

Gene name

PGC

Synonyms

Description

progastricsin (pepsinogen C) (HGNC Symbol)

Entrez gene summary

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

Chromosome

6 (Chromosome progress)

Cytoband

p21.1

Chromosome location (bp)

41704449 - 41721847

Ensembl

ENSG00000096088 (version 73.37)

Entrez gene

5225

UniProt

P20142 (UniProt - Evidence at protein level)

neXtProt

NX_P20142

Antibodypedia

PGC antibodies
 

PROTEIN VIEW

? »
 
 
 
PGC-001
 
PGC-003
 
PGC-004
 
PGC-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PGC-001 ENSP00000362116
ENST00000373025
P20142
Show all »
Show » Show » 388 42.4 Yes 0
PGC-003 ENSP00000349094
ENST00000356667
Q4VXA6
Show all »
Show » 140 15.7 Yes 0
PGC-004 ENSP00000399429
ENST00000415707
A2A3L9
Show all »
Show » 86 10 No 0
PGC-201 ENSP00000405094
ENST00000425343
P20142
Show all »
Show » Show » 315 34.2 Yes 0