SIRT1

GENE INFORMATION

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Gene name

SIRT1 (HGNC Symbol)

Synonyms

SIR2L1

Description

sirtuin 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

Chromosome

10 (Chromosome progress)

Cytoband

q21.3

Chromosome location (bp)

69644427 - 69678147

Ensembl

ENSG00000096717 (version 73.37)

Entrez gene

23411

UniProt

Q96EB6 (UniProt - Evidence at protein level)

neXtProt

NX_Q96EB6

Antibodypedia

SIRT1 antibodies
 

PROTEIN VIEW

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SIRT1-001
 
SIRT1-002
 
SIRT1-003
 
SIRT1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SIRT1-001 ENSP00000212015
ENST00000212015
Q96EB6
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Show » 747 81.7 No 0
SIRT1-002 ENSP00000384508
ENST00000406900
B0QZ35
Show all »
Show » 444 49.2 No 0
SIRT1-003 ENSP00000384063
ENST00000403579
B0QZ35
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Show » 444 49.2 No 0
SIRT1-201 ENSP00000409208
ENST00000432464
E9PC49
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Show » 452 50.5 No 0