ABL1

GENERAL INFORMATION

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Gene name

ABL1

Gene description

ABL proto-oncogene 1, non-receptor tyrosine kinase

Protein class

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and nuclear expression at variable levels in all tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 4 antibodies.
HPA027251 , HPA027280 , HPA028409 , CAB002686
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ABL1 (HGNC Symbol)

Synonyms

ABL, c-ABL, JTK7, p150

Description

ABL proto-oncogene 1, non-receptor tyrosine kinase (HGNC Symbol)

Entrez gene summary

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]

Chromosome

9

Cytoband

q34.12

Chromosome location (bp)

130713946 - 130887675

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000097007 (version 78.38)

Entrez gene

25

UniProt

P00519 (UniProt - Evidence at protein level)

neXtProt

NX_P00519

Antibodypedia

ABL1 antibodies


PROTEIN BROWSER

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ENST00000318560
 
ENST00000372348
 
ENST00000393293
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABL1-001 ENSP00000323315
ENST00000318560
P00519
Show all »
Show » Show » 1130 122.9 No 0
ABL1-002 ENSP00000361423
ENST00000372348
P00519
Show all »
Show » Show » 1149 125 No 0
ABL1-003 ENSP00000376971
ENST00000393293
R4GRW0
Show all »
Show » 64 6.9 No 0