ABL1

GENE INFORMATION

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Gene name

ABL1 (HGNC Symbol)

Synonyms

ABL, c-ABL, JTK7, p150

Description

c-abl oncogene 1, non-receptor tyrosine kinase (HGNC Symbol)

Entrez gene summary

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008]

Chromosome

9 (Chromosome progress)

Cytoband

q34.12

Chromosome location (bp)

133589333 - 133763062

Ensembl

ENSG00000097007 (version 73.37)

Entrez gene

25

UniProt

P00519 (UniProt - Evidence at protein level)

neXtProt

NX_P00519

Antibodypedia

ABL1 antibodies
 

PROTEIN VIEW

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ABL1-001
 
ABL1-002
 
ABL1-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABL1-001 ENSP00000323315
ENST00000318560
P00519
Show all »
Show » Show » 1130 122.9 No 0
ABL1-002 ENSP00000361423
ENST00000372348
P00519
Show all »
Show » Show » 1149 125 No 0
ABL1-003 ENSP00000376971
ENST00000393293
R4GRW0
Show all »
Show » 64 6.9 No 0