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GENE INFORMATION

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Gene name

PSMD8 (HGNC Symbol)

Synonyms

HIP6, HYPF, Nin1p, p31, Rpn12, S14

Description

proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 (HGNC Symbol)

Entrez gene summary

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

38865176 - 38874464

Ensembl

ENSG00000099341 (version 69.37)

Entrez gene

5714

UniProt

P48556

neXtProt

NX_P48556

Antibodypedia

PSMD8 antibodies
 

PROTEIN VIEW

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PSMD8-001
 
PSMD8-002
 
PSMD8-004
 
PSMD8-005
 
PSMD8-008
 
PSMD8-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMD8-001 ENSP00000215071
ENST00000215071
P48556
Show all »
Show » Show » 350 39.6 No 0
PSMD8-002 ENSP00000465107
ENST00000592035
172 19.8 No 0
PSMD8-004 ENSP00000465287
ENST00000592561
Show » 258 28.8 Yes 0
PSMD8-005 ENSP00000467146
ENST00000585598
Show » 140 14.5 No 0
PSMD8-008 ENSP00000468445
ENST00000591250
67 8 No 0
PSMD8-009 ENSP00000465418
ENST00000590331
Show » 63 6.9 No 1