IGFALS

GENE INFORMATION

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Gene name

IGFALS (HGNC Symbol)

Synonyms

ALS

Description

insulin-like growth factor binding protein, acid labile subunit (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

16 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

1840414 - 1844972

Ensembl

ENSG00000099769 (version 73.37)

Entrez gene

3483

UniProt

P35858 (UniProt - Evidence at protein level)

neXtProt

NX_P35858

Antibodypedia

IGFALS antibodies
 

PROTEIN VIEW

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IGFALS-001
 
IGFALS-002
 
IGFALS-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IGFALS-001 ENSP00000215539
ENST00000215539
P35858
Show all »
Show » Show » 605 66 Yes 0
IGFALS-002 ENSP00000416683
ENST00000415638
P35858
Show all »
Show » Show » 643 70.2 No 1
IGFALS-004 ENSP00000456923
ENST00000568221
H3BSX8
Show all »
131 14.4 No 0