MKNK2

GENE INFORMATION

? »

Gene name

MKNK2 (HGNC Symbol)

Synonyms

GPRK7, MNK2

Description

MAP kinase interacting serine/threonine kinase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]

Chromosome

19 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

2037470 - 2051243

Ensembl

ENSG00000099875 (version 73.37)

Entrez gene

2872

UniProt

Q9HBH9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HBH9

Antibodypedia

MKNK2 antibodies
 

PROTEIN VIEW

? »
 
 
 « 
 
MKNK2-001
 
MKNK2-003
 
MKNK2-004
 
MKNK2-005
 
MKNK2-006
 
MKNK2-009
 
MKNK2-010
 
MKNK2-012
 
MKNK2-013
 
MKNK2-201
 
MKNK2-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MKNK2-001 ENSP00000309485
ENST00000309340
Q9HBH9
Show all »
Show » Show » 414 46.7 No 0
MKNK2-003 ENSP00000465425
ENST00000586828
K7EK27
Show all »
82 9.2 No 0
MKNK2-004 ENSP00000467811
ENST00000591601
Q9HBH9
Show all »
Show » Show » 465 51.9 No 0
MKNK2-005 ENSP00000465645
ENST00000591142
Q9NV89
Show all »
Show » Show » 158 17.7 No 0
MKNK2-006 ENSP00000466147
ENST00000589509
K7ELN0
Show all »
70 7.7 No 0
MKNK2-009 ENSP00000464828
ENST00000591588
K7EIN7
Show all »
Show » Show » 129 14.4 No 0
MKNK2-010 ENSP00000465079
ENST00000588014
K7EIN7
Show all »
Show » Show » 129 14.4 No 0
MKNK2-012 ENSP00000466064
ENST00000589534
K7ELG3
Show all »
85 9.1 No 0
MKNK2-013 ENSP00000466594
ENST00000589441
K7EMP5
Show all »
Show » 174 19.2 No 0
MKNK2-201 ENSP00000250896
ENST00000250896
Q9HBH9
Show all »
Show » Show » 465 51.9 No 0
MKNK2-202 ENSP00000438904
ENST00000541165
B4DEQ4
Show all »
Show » Show » 334 37.1 No 0