MAPK1

GENERAL INFORMATION

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Gene name

MAPK1

Gene description

Mitogen-activated protein kinase 1

Protein class

Cancer-related genes
Cytoskeleton related proteins
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation. Caution, targets protein from more than one gene.

Data reliability

Supportive based on 4 antibodies.
HPA003995 , HPA005700 , HPA030069 , CAB004229
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MAPK1 (HGNC Symbol)

Synonyms

ERK, ERK2, MAPK2, p41mapk, PRKM1, PRKM2

Description

Mitogen-activated protein kinase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]

Chromosome

22

Cytoband

q11.22

Chromosome location (bp)

21754500 - 21867680

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100030 (version 78.38)

Entrez gene

5594

UniProt

P28482 (UniProt - Evidence at protein level)

neXtProt

NX_P28482

Antibodypedia

MAPK1 antibodies


PROTEIN BROWSER

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ENST00000215832
 
ENST00000398822
 
ENST00000544786
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAPK1-001 ENSP00000215832
ENST00000215832
P28482
Show all »
Show » Show » 360 41.4 No 0
MAPK1-002 ENSP00000381803
ENST00000398822
P28482
Show all »
Show » Show » 360 41.4 No 0
MAPK1-201 ENSP00000440842
ENST00000544786
P28482
Show all »
Show » Show » 316 36.4 No 0