MAPK1

GENE INFORMATION

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Gene name

MAPK1 (HGNC Symbol)

Synonyms

ERK, ERK2, MAPK2, p41mapk, PRKM1, PRKM2

Description

mitogen-activated protein kinase 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jul 2008]

Chromosome

22 (Chromosome progress)

Cytoband

q11.21

Chromosome location (bp)

22108789 - 22221970

Ensembl

ENSG00000100030 (version 73.37)

Entrez gene

5594

UniProt

P28482 (UniProt - Evidence at protein level)

neXtProt

NX_P28482

Antibodypedia

MAPK1 antibodies
 

PROTEIN VIEW

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MAPK1-001
 
MAPK1-002
 
MAPK1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAPK1-001 ENSP00000215832
ENST00000215832
P28482
Show all »
Show » Show » 360 41.4 No 0
MAPK1-002 ENSP00000381803
ENST00000398822
P28482
Show all »
Show » Show » 360 41.4 No 0
MAPK1-201 ENSP00000440842
ENST00000544786
A8CZ64
Show all »
Show » Show » 316 36.4 No 0