PRODH

GENERAL INFORMATION

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Gene name

PRODH

Gene description

Proline dehydrogenase (oxidase) 1

Protein class

Disease related genes
Enzymes
Mitochondrial proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (small intestine)
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.

Data reliability

Uncertain based on 1 antibody.
HPA020361
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (small intestine)

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

PRODH (HGNC Symbol)

Synonyms

HSPOX2, PIG6, PRODH1, PRODH2, TP53I6

Description

Proline dehydrogenase (oxidase) 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

Chromosome

22

Cytoband

q11.21

Chromosome location (bp)

18912777 - 18936553

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100033 (version 78.38)

Entrez gene

5625

UniProt

O43272 (UniProt - Evidence at protein level)

neXtProt

NX_O43272

Antibodypedia

PRODH antibodies


PROTEIN BROWSER

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ENST00000334029
 
ENST00000357068
 
ENST00000420436
 
ENST00000438924
 
ENST00000450579
 
ENST00000457083
 
ENST00000610940
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRODH-001 ENSP00000349577
ENST00000357068
O43272
Show all »
Show » Show » 600 68 No 0
PRODH-002 ENSP00000334726
ENST00000334029
E7EQL6
Show all »
Show » Show » 492 56.3 No 0
PRODH-004 ENSP00000410805
ENST00000420436
E7EQL6
Show all »
Show » Show » 492 56.3 No 0
PRODH-009 ENSP00000413941
ENST00000457083
Show » 164 16.6 No 0
PRODH-010 ENSP00000396806
ENST00000450579
C9JIW4
Show all »
Show » Show » 135 15 No 0
PRODH-011 ENSP00000409742
ENST00000438924
Show » 185 19.1 No 0
PRODH-201 ENSP00000480347
ENST00000610940
E7EQL6
Show all »
Show » Show » 600 68 No 0