PATZ1

GENE INFORMATION

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Gene name

PATZ1 (HGNC Symbol)

Synonyms

dJ400N23, MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG

Description

POZ (BTB) and AT hook containing zinc finger 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

22 (Chromosome progress)

Cytoband

q12.2

Chromosome location (bp)

31721790 - 31742218

Ensembl

ENSG00000100105 (version 73.37)

Entrez gene

23598

UniProt

Q9HBE1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HBE1

Antibodypedia

PATZ1 antibodies
 

PROTEIN VIEW

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PATZ1-001
 
PATZ1-002
 
PATZ1-003
 
PATZ1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PATZ1-001 ENSP00000266269
ENST00000266269
Q9HBE1
Show all »
Show » Show » 687 74.1 No 0
PATZ1-002 ENSP00000384173
ENST00000405309
Q9HBE1
Show all »
Show » Show » 537 58 No 0
PATZ1-003 ENSP00000215919
ENST00000215919
Q9HBE1
Show all »
Show » Show » 537 57.6 No 0
PATZ1-004 ENSP00000337520
ENST00000351933
Q9HBE1
Show all »
Show » Show » 641 69.1 No 0