GGTLC2

GENERAL INFORMATION

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Gene name

GGTLC2

Gene description

Gamma-glutamyltransferase light chain 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests selective expression in testis, RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Pending external verification. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Data reliability

Supportive based on 2 antibodies.
HPA045635 , HPA047534
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Epididymis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

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Gene name

GGTLC2 (HGNC Symbol)

Synonyms

GGTL4

Description

Gamma-glutamyltransferase light chain 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein related to enzymes that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides. Unlike similar proteins, the encoded protein contains only the light chain portion and may not have catalytic activity. Alternative splicing results in multiple transcript variants. There are several related family members and related pseudogene for this gene situated in the same region of chromosome 22. [provided by RefSeq, Sep 2013]

Chromosome

22

Cytoband

q11.22

Chromosome location (bp)

22644475 - 22647903

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100121 (version 78.38)

Entrez gene

91227

UniProt

Q14390 (UniProt - Evidence at transcript level)

neXtProt

NX_Q14390

Antibodypedia

GGTLC2 antibodies


PROTEIN BROWSER

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ENST00000448514
 
ENST00000480559
 
ENST00000613850
 
ENST00000618722
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GGTLC2-001 ENSP00000419751
ENST00000480559
Q14390
Show all »
Show » Show » 218 23.7 No 0
GGTLC2-003 ENSP00000415676
ENST00000448514
Q14390
Show all »
Show » Show » 225 24.2 No 0
GGTLC2-201 ENSP00000478615
ENST00000613850
Q14390
Show all »
Show » Show » 225 24.2 No 0
GGTLC2-202 ENSP00000483019
ENST00000618722
Q14390
Show all »
Show » Show » 225 24.2 No 0