CYP2D6

GENE INFORMATION

? »

Gene name

CYP2D6 (HGNC Symbol)

Synonyms

CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, P450-DB1, P450C2D

Description

cytochrome P450, family 2, subfamily D, polypeptide 6 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

22 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

42522501 - 42526908

Ensembl

ENSG00000100197 (version 73.37)

Entrez gene

1565

UniProt

P10635 (UniProt - Evidence at protein level)

neXtProt

NX_P10635

Antibodypedia

CYP2D6 antibodies
 

PROTEIN VIEW

? »
 
 
 
CYP2D6-001
 
CYP2D6-002
 
CYP2D6-003
 
CYP2D6-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP2D6-001 ENSP00000353820
ENST00000360608
Q6NWU0
Show all »
Show » Show » 497 55.7 No 2
CYP2D6-002 ENSP00000351927
ENST00000359033
P10635
Show all »
Show » Show » 446 50 No 2
CYP2D6-003 ENSP00000353241
ENST00000360124
H7BY38
Show all »
Show » 180 20.3 No 0
CYP2D6-201 ENSP00000374620
ENST00000389970
E7ENE7
Show all »
Show » Show » 497 55.7 No 2