TSPO

GENERAL INFORMATION

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Gene name

TSPO

Gene description

Translocator protein (18kDa)

Protein class

Cancer-related genes
FDA approved drug targets
Mitochondrial proteins
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues showed weak to moderate cytoplasmic staining.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB011232
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

TSPO (HGNC Symbol)

Synonyms

BZRP, DBI, IBP, MBR, mDRC, PBR, pk18, PKBS

Description

Translocator protein (18kDa) (HGNC Symbol)

Entrez gene summary

Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012]

Chromosome

22

Cytoband

q13.2

Chromosome location (bp)

43151514 - 43163242

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100300 (version 78.38)

Entrez gene

706

UniProt

B1AH88 (UniProt - Uncertain,UniProt - Evidence at protein level), P30536 (UniProt - Evidence at protein level,UniProt - Uncertain)

neXtProt

NX_B1AH88, NX_P30536

Antibodypedia

TSPO antibodies


PROTEIN BROWSER

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ENST00000329563
 
ENST00000337554
 
ENST00000396265
 
ENST00000428336
 
ENST00000583777
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TSPO-001 ENSP00000338004
ENST00000337554
P30536
Show all »
Show » Show » 169 18.8 No 5
TSPO-002 ENSP00000463495
ENST00000583777
J3QLD3
Show all »
Show » Show » 65 7.3 Yes 1
TSPO-004 ENSP00000328973
ENST00000329563
P30536
Show all »
Show » Show » 169 18.8 No 5
TSPO-005 ENSP00000405685
ENST00000428336
B1AH87
Show all »
Show » Show » 107 11.9 No 1
TSPO-201 ENSP00000379563
ENST00000396265
B1AH88
Show all »
Show » Show » 169 18.8 No 5