PDGFB

GENE INFORMATION

? »

Gene name

PDGFB (HGNC Symbol)

Synonyms

SIS, SSV

Description

platelet-derived growth factor beta polypeptide (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2013]

Chromosome

22 (Chromosome progress)

Cytoband

q13.1

Chromosome location (bp)

39619364 - 39640756

Ensembl

ENSG00000100311 (version 73.37)

Entrez gene

5155

UniProt

P01127 (UniProt - Evidence at protein level)

neXtProt

NX_P01127

Antibodypedia

PDGFB antibodies
 

PROTEIN VIEW

? »
 
 
 
PDGFB-001
 
PDGFB-002
 
PDGFB-003
 
PDGFB-004
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDGFB-001 ENSP00000330382
ENST00000331163
P01127
Show all »
Show » Show » 241 27.3 Yes 0
PDGFB-002 ENSP00000370963
ENST00000381551
P01127
Show all »
Show » Show » 226 25.5 No 0
PDGFB-003 ENSP00000402306
ENST00000455790
A9UJP0
Show all »
Show » Show » 144 16.3 No 0
PDGFB-004 ENSP00000405780
ENST00000440375
A9UJN9
Show all »
Show » Show » 136 15.5 No 0