ACR

GENE INFORMATION

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Gene name

ACR

Synonyms

Description

acrosin (HGNC Symbol)

Entrez gene summary

Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]

Chromosome

22 (Chromosome progress)

Cytoband

q13.33

Chromosome location (bp)

51176624 - 51183762

Ensembl

ENSG00000100312 (version 73.37)

Entrez gene

49

UniProt

P10323 (UniProt - Evidence at transcript level)

neXtProt

NX_P10323

Antibodypedia

ACR antibodies
 

PROTEIN VIEW

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ACR-001
 
ACR-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACR-001 ENSP00000216139
ENST00000216139
P10323
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Show » Show » 421 45.8 Yes 0
ACR-003 ENSP00000435120
ENST00000529621
E9PLV5
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Show » Show » 212 23.1 Yes 0