NCF4

GENE INFORMATION

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Gene name

NCF4 (HGNC Symbol)

Synonyms

p40phox, SH3PXD4

Description

neutrophil cytosolic factor 4, 40kDa (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Chromosome

22 (Chromosome progress)

Cytoband

q12.3

Chromosome location (bp)

37257030 - 37274057

Ensembl

ENSG00000100365 (version 73.37)

Entrez gene

4689

UniProt

Q15080 (UniProt - Evidence at protein level)

neXtProt

NX_Q15080

Antibodypedia

NCF4 antibodies
 

PROTEIN VIEW

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NCF4-001
 
NCF4-002
 
NCF4-003
 
NCF4-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NCF4-001 ENSP00000248899
ENST00000248899
Q15080
Show all »
Show » Show » 339 39 No 0
NCF4-002 ENSP00000380334
ENST00000397147
Q15080
Show all »
Show » Show » 348 39 No 0
NCF4-003 ENSP00000408619
ENST00000415063
Show » Show » 212 23.1 No 0
NCF4-004 ENSP00000414958
ENST00000447071
B0QY04
Show all »
Show » Show » 166 18.9 No 0