EP300

GENE INFORMATION

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Gene name

EP300 (HGNC Symbol)

Synonyms

KAT3B, p300

Description

E1A binding protein p300 (HGNC Symbol)

Entrez gene summary

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]

Chromosome

22 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

41487790 - 41576081

Ensembl

ENSG00000100393 (version 73.37)

Entrez gene

2033

UniProt

Q09472 (UniProt - Evidence at protein level)

neXtProt

NX_Q09472

Antibodypedia

EP300 antibodies
 

PROTEIN VIEW

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EP300-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EP300-001 ENSP00000263253
ENST00000263253
Q09472
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