KCNK10

GENERAL INFORMATION

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Gene name

KCNK10

Gene description

Potassium channel, subfamily K, member 10

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (cerebral cortex, duodenum)
GTEx:Tissue enhanced (cerebellum, hippocampus)

Protein evidence

Evidence at protein level

Protein localization

Strong cytoplasmic positivity was observed in exocrine pancreas. Respiratory epithelium, gastrointestinal tract, salivary glands and subsets of neuronal cells showed moderate staining. The remaining normal tissues were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA030462
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (cerebral cortex, duodenum)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebellum, hippocampus)

Organ

Expression



GENE INFORMATION

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Gene name

KCNK10 (HGNC Symbol)

Synonyms

K2p10.1, PPP1R97, TREK-2, TREK2

Description

Potassium channel, subfamily K, member 10 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]

Chromosome

14

Cytoband

q31.3

Chromosome location (bp)

88180103 - 88326907

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100433 (version 78.38)

Entrez gene

54207

UniProt

P57789 (UniProt - Evidence at protein level)

neXtProt

NX_P57789

Antibodypedia

KCNK10 antibodies


PROTEIN BROWSER

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ENST00000312350
 
ENST00000319231
 
ENST00000340700
 
ENST00000556282
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNK10-001 ENSP00000343104
ENST00000340700
P57789
Show all »
Show » Show » 538 59.8 Yes 6
KCNK10-002 ENSP00000312811
ENST00000319231
Show » Show » 543 60.3 No 6
KCNK10-003 ENSP00000310568
ENST00000312350
Show » 543 60.1 No 6
KCNK10-004 ENSP00000452587
ENST00000556282
G3V5Y5
Show all »
Show » Show » 157 16.5 No 1