GZMH

GENE INFORMATION

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Gene name

GZMH (HGNC Symbol)

Synonyms

CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2

Description

granzyme H (cathepsin G-like 2, protein h-CCPX) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the granzyme family. Members of this family are highly conserved serine proteases that eliminate transformed cells and virus-infected cells. This protein, which has chymotrypsin-like activity, has a preference for bulky aromatic amino acids at the P1 position and for acidic residues at the P3' and P4' positions. This protein is reported to be constitutively expressed in NK cells and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Chromosome

14 (Chromosome progress)

Cytoband

q12

Chromosome location (bp)

25075686 - 25078905

Ensembl

ENSG00000100450 (version 73.37)

Entrez gene

2999

UniProt

P20718 (UniProt - Evidence at protein level)

neXtProt

NX_P20718

Antibodypedia

GZMH antibodies
 

PROTEIN VIEW

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GZMH-001
 
GZMH-002
 
GZMH-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GZMH-001 ENSP00000216338
ENST00000216338
P20718
Show all »
Show » Show » 246 27.3 Yes 0
GZMH-002 ENSP00000450576
ENST00000557220
Q6XGZ0
Show all »
Show » 115 12.7 Yes 0
GZMH-003 ENSP00000371988
ENST00000382548
P20718
Show all »
Show » Show » 160 17.8 Yes 0