GZMB

GENE INFORMATION

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Gene name

GZMB (HGNC Symbol)

Synonyms

CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT

Description

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (HGNC Symbol)

Entrez gene summary

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008]

Chromosome

14 (Chromosome progress)

Cytoband

q12

Chromosome location (bp)

25100160 - 25103473

Ensembl

ENSG00000100453 (version 73.37)

Entrez gene

3002

UniProt

P10144 (UniProt - Evidence at protein level)

neXtProt

NX_P10144

Antibodypedia

GZMB antibodies
 

PROTEIN VIEW

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GZMB-001
 
GZMB-003
 
GZMB-004
 
GZMB-005
 
GZMB-006
 
GZMB-007
 
GZMB-201
 
GZMB-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GZMB-001 ENSP00000216341
ENST00000216341
P10144
Show all »
Show » Show » 247 27.7 Yes 0
GZMB-003 ENSP00000387385
ENST00000415355
J3KQ52
Show all »
Show » Show » 235 26.4 No 0
GZMB-004 ENSP00000432074
ENST00000532263
E9PID1
Show all »
35 3.6 Yes 0
GZMB-005 ENSP00000434213
ENST00000526004
E9PRD7
Show all »
Show » 90 10.2 Yes 0
GZMB-006 ENSP00000435084
ENST00000530830
E9PLX4
Show all »
44 4.9 No 0
GZMB-007 ENSP00000450535
ENST00000554242
E9PRD7
Show all »
Show » 90 10.2 Yes 0
GZMB-201 ENSP00000371980
ENST00000382540
E7EUV0
Show all »
Show » 202 22.7 Yes 0
GZMB-202 ENSP00000371982
ENST00000382542
J3KPK2
Show all »
Show » Show » 281 31.4 Yes 0