CDKN3

GENERAL INFORMATION

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Gene name

CDKN3

Gene description

Cyclin-dependent kinase inhibitor 3

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression in testis. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Pending external verification. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 2 antibodies.
HPA039311 , CAB005285
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

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Gene name

CDKN3 (HGNC Symbol)

Synonyms

CDI1, KAP

Description

Cyclin-dependent kinase inhibitor 3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Chromosome

14

Cytoband

q22.2

Chromosome location (bp)

54396849 - 54420218

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100526 (version 78.38)

Entrez gene

1033

UniProt

Q16667 (UniProt - Evidence at protein level)

neXtProt

NX_Q16667

Antibodypedia

CDKN3 antibodies


PROTEIN BROWSER

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ENST00000335183
 
ENST00000395577
 
ENST00000442975
 
ENST00000458126
 
ENST00000541304
 
ENST00000543789
 
ENST00000556102
 
ENST00000611205
 
ENST00000620759
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDKN3-001 ENSP00000335357
ENST00000335183
Q16667
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Show » Show » 212 23.8 No 0
CDKN3-002 ENSP00000396451
ENST00000458126
H7C0S3
Show all »
Show » Show » 211 23.7 No 0
CDKN3-003 ENSP00000415333
ENST00000442975
Q16667
Show all »
Show » Show » 172 19.4 No 0
CDKN3-004 ENSP00000445572
ENST00000541304
F5H232
Show all »
Show » Show » 146 16.5 No 0
CDKN3-009 ENSP00000440404
ENST00000543789
G3V1K6
Show all »
Show » Show » 148 16.6 No 0
CDKN3-010 ENSP00000450711
ENST00000556102
G3V2J7
Show all »
Show » Show » 203 22.5 No 0
CDKN3-201 ENSP00000378944
ENST00000395577
F8WD24
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Show » Show » 166 18.7 No 0
CDKN3-202 ENSP00000480289
ENST00000611205
Show » Show » 207 23.1 No 0
CDKN3-203 ENSP00000479875
ENST00000620759
Show » Show » 35 4 No 0