LGMN

GENE INFORMATION

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Gene name

LGMN (HGNC Symbol)

Synonyms

LGMN1, PRSC1

Description

legumain (HGNC Symbol)

Entrez gene summary

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]

Chromosome

14 (Chromosome progress)

Cytoband

q32.12

Chromosome location (bp)

93170152 - 93215047

Ensembl

ENSG00000100600 (version 73.37)

Entrez gene

5641

UniProt

Q99538 (UniProt - Evidence at protein level)

neXtProt

NX_Q99538

Antibodypedia

LGMN antibodies
 

PROTEIN VIEW

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LGMN-001
 
LGMN-002
 
LGMN-004
 
LGMN-005
 
LGMN-007
 
LGMN-009
 
LGMN-010
 
LGMN-011
 
LGMN-012
 
LGMN-013
 
LGMN-015
 
LGMN-018
 
LGMN-019
 
LGMN-020
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LGMN-001 ENSP00000334052
ENST00000334869
Q99538
Show all »
Show » Show » 433 49.4 Yes 0
LGMN-002 ENSP00000452572
ENST00000557434
Q86TV3
Show all »
Show » 376 42.9 Yes 0
LGMN-004 ENSP00000451861
ENST00000555699
Q86TV2
Show all »
Show » 372 42 Yes 0
LGMN-005 ENSP00000376911
ENST00000393218
Q99538
Show all »
Show » Show » 433 49.4 Yes 0
LGMN-007 ENSP00000451507
ENST00000557609
G3V3Z4
Show all »
Show » 117 13 Yes 0
LGMN-009 ENSP00000451797
ENST00000553371
G3V4H2
Show all »
Show » 57 6.3 Yes 0
LGMN-010 ENSP00000452268
ENST00000554080
G3V5B2
Show all »
Show » 58 6.4 Yes 0
LGMN-011 ENSP00000450677
ENST00000554397
G3V4P5
Show all »
Show » 78 8.7 Yes 0
LGMN-012 ENSP00000450854
ENST00000553802
G3V2T4
Show all »
Show » 135 14.6 Yes 0
LGMN-013 ENSP00000450483
ENST00000554189
G3V263
Show all »
Show » 48 5.3 Yes 0
LGMN-015 ENSP00000451916
ENST00000554919
G3V4P5
Show all »
Show » 78 8.7 Yes 0
LGMN-018 ENSP00000450619
ENST00000553918
19 2 No 0
LGMN-019 ENSP00000451746
ENST00000556097
G3V4E4
Show all »
Show » 223 25.1 Yes 0
LGMN-020 ENSP00000451854
ENST00000555169
Show » 91 9.7 No 0