HIF1A

GENE INFORMATION

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Gene name

HIF1A (HGNC Symbol)

Synonyms

bHLHe78, HIF-1alpha, HIF1, MOP1, PASD8

Description

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (HGNC Symbol)

Entrez gene summary

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]

Chromosome

14 (Chromosome progress)

Cytoband

q23.2

Chromosome location (bp)

62162231 - 62214976

Ensembl

ENSG00000100644 (version 73.37)

Entrez gene

3091

UniProt

Q16665 (UniProt - Evidence at protein level)

neXtProt

NX_Q16665

Antibodypedia

HIF1A antibodies
 

PROTEIN VIEW

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HIF1A-001
 
HIF1A-002
 
HIF1A-003
 
HIF1A-004
 
HIF1A-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HIF1A-001 ENSP00000338018
ENST00000337138
Q16665
Show all »
Show » Show » 826 92.7 No 0
HIF1A-002 ENSP00000323326
ENST00000323441
Q16665
Show all »
Show » Show » 735 82.7 No 0
HIF1A-003 ENSP00000378446
ENST00000394997
A8MYV6
Show all »
Show » Show » 827 92.8 No 0
HIF1A-004 ENSP00000451696
ENST00000557538
F8W9L0
Show all »
Show » Show » 767 86.1 No 0
HIF1A-201 ENSP00000437955
ENST00000539097
Q16665
Show all »
Show » Show » 850 95.6 No 0