SLC10A1

GENE INFORMATION

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Gene name

SLC10A1 (HGNC Symbol)

Synonyms

NTCP

Description

solute carrier family 10 (sodium/bile acid cotransporter family), member 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]

Chromosome

14 (Chromosome progress)

Cytoband

q24.2

Chromosome location (bp)

70242134 - 70264006

Ensembl

ENSG00000100652 (version 73.37)

Entrez gene

6554

UniProt

Q14973 (UniProt - Evidence at transcript level)

neXtProt

NX_Q14973

Antibodypedia

SLC10A1 antibodies
 

PROTEIN VIEW

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SLC10A1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC10A1-001 ENSP00000216540
ENST00000216540
Q14973
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