VRK1

GENE INFORMATION

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Gene name

VRK1

Synonyms

Description

vaccinia related kinase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]

Chromosome

14 (Chromosome progress)

Cytoband

q32.2

Chromosome location (bp)

97263641 - 97398059

Ensembl

ENSG00000100749 (version 73.37)

Entrez gene

7443

UniProt

Q99986 (UniProt - Evidence at protein level)

neXtProt

NX_Q99986

Antibodypedia

VRK1 antibodies
 

PROTEIN VIEW

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VRK1-001
 
VRK1-003
 
VRK1-005
 
VRK1-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VRK1-001 ENSP00000216639
ENST00000216639
Q99986
Show all »
Show » Show » 396 45.5 No 0
VRK1-003 ENSP00000450820
ENST00000557222
Show » 232 26.6 No 0
VRK1-005 ENSP00000451412
ENST00000553683
65 7.4 No 0
VRK1-006 ENSP00000451682
ENST00000557352
Show » Show » 176 19.9 No 1