PSMB5

GENE INFORMATION

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Gene name

PSMB5 (HGNC Symbol)

Synonyms

MB1, X

Description

proteasome (prosome, macropain) subunit, beta type, 5 (HGNC Symbol)

Entrez gene summary

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Chromosome

14 (Chromosome progress)

Cytoband

q11.2

Chromosome location (bp)

23485752 - 23504439

Ensembl

ENSG00000100804 (version 73.37)

Entrez gene

5693

UniProt

P28074 (UniProt - Evidence at protein level)

neXtProt

NX_P28074

Antibodypedia

PSMB5 antibodies
 

PROTEIN VIEW

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PSMB5-001
 
PSMB5-002
 
PSMB5-004
 
PSMB5-005
 
PSMB5-006
 
PSMB5-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMB5-001 ENSP00000451286
ENST00000460922
G3V3K3
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84 8.6 No 0
PSMB5-002 ENSP00000355325
ENST00000361611
P28074
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Show » Show » 263 28.5 No 0
PSMB5-004 ENSP00000452424
ENST00000493471
P28074
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Show » Show » 203 21.8 No 0
PSMB5-005 ENSP00000395206
ENST00000425762
P28074
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Show » Show » 160 17.8 No 0
PSMB5-006 ENSP00000334973
ENST00000334454
G8JLC2
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77 8.1 No 0
PSMB5-007 ENSP00000451816
ENST00000555895
Show » Show » 118 12.7 No 0