APEX1

GENE INFORMATION

? »

Gene name

APEX1 (HGNC Symbol)

Synonyms

APE, APE-1, APEN, APEX, APX, HAP1, REF-1, REF1

Description

APEX nuclease (multifunctional DNA repair enzyme) 1 (HGNC Symbol)

Entrez gene summary

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]

Chromosome

14 (Chromosome progress)

Cytoband

q11.2

Chromosome location (bp)

20923350 - 20925927

Ensembl

ENSG00000100823 (version 73.37)

Entrez gene

328

UniProt

P27695 (UniProt - Evidence at protein level)

neXtProt

NX_P27695

Antibodypedia

APEX1 antibodies
 

PROTEIN VIEW

? »
 
 
 « 
 
APEX1-001
 
APEX1-002
 
APEX1-003
 
APEX1-006
 
APEX1-008
 
APEX1-009
 
APEX1-013
 
APEX1-014
 
APEX1-015
 
APEX1-016
 
APEX1-017
 
APEX1-018
 
APEX1-019
 
APEX1-021
 
 » 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APEX1-001 ENSP00000216714
ENST00000216714
P27695
Show all »
Show » Show » 318 35.6 No 0
APEX1-002 ENSP00000451979
ENST00000555414
P27695
Show all »
Show » Show » 318 35.6 No 0
APEX1-003 ENSP00000416414
ENST00000438886
Show » 150 16.7 No 0
APEX1-006 ENSP00000452212
ENST00000557054
14 1.5 No 0
APEX1-008 ENSP00000381111
ENST00000398030
P27695
Show all »
Show » Show » 318 35.6 No 0
APEX1-009 ENSP00000451327
ENST00000553681
G3V3M6
Show all »
Show » 263 29.2 No 0
APEX1-013 ENSP00000452137
ENST00000557344
P27695
Show all »
Show » Show » 146 15.9 No 0
APEX1-014 ENSP00000452304
ENST00000557181
G3V5D9
Show all »
Show » 108 11.8 No 0
APEX1-015 ENSP00000450604
ENST00000554325
G3V2D9
Show all »
49 5.1 No 0
APEX1-016 ENSP00000452460
ENST00000555839
G3V5Q1
Show all »
Show » 242 27.1 No 0
APEX1-017 ENSP00000451170
ENST00000556054
G3V3C7
Show all »
Show » 174 19.1 No 0
APEX1-018 ENSP00000451060
ENST00000557592
G3V359
Show all »
Show » 172 19.2 No 0
APEX1-019 ENSP00000451491
ENST00000553368
G3V3Y6
Show all »
42 4.5 No 0
APEX1-021 ENSP00000452418
ENST00000557150
G3V5M0
Show all »
Show » 162 17.8 No 0