EFS

GENERAL INFORMATION

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Gene name

EFS

Gene description

Embryonal Fyn-associated substrate

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Bile ducts in liver showed strong cytoplasmic reactivity. Glial cells and subsets of cells in cerebellum displayed moderate nuclear staining. Squamous epithelia showed a moderate nuclear and cytoplasmic staining. Remaining normal cells were in general weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA001581
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

EFS (HGNC Symbol)

Synonyms

CASS3, EFS1, EFS2, HEFS, SIN

Description

Embryonal Fyn-associated substrate (HGNC Symbol)

Entrez gene summary

The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2013]

Chromosome

14

Cytoband

q11.2

Chromosome location (bp)

23356402 - 23365752

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100842 (version 78.38)

Entrez gene

10278

UniProt

O43281 (UniProt - Evidence at transcript level)

neXtProt

NX_O43281

Antibodypedia

EFS antibodies


PROTEIN BROWSER

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ENST00000216733
 
ENST00000351354
 
ENST00000429593
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EFS-001 ENSP00000340607
ENST00000351354
O43281
Show all »
Show » Show » 468 49 No 0
EFS-003 ENSP00000216733
ENST00000216733
O43281
Show all »
Show » Show » 561 58.8 No 0
EFS-201 ENSP00000416684
ENST00000429593
O43281
Show all »
Show » Show » 392 41 No 0