PSMA6

GENE INFORMATION

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Gene name

PSMA6 (HGNC Symbol)

Synonyms

IOTA, MGC22756, MGC2333, MGC23846, p27K, PROS27

Description

proteasome (prosome, macropain) subunit, alpha type, 6 (HGNC Symbol)

Entrez gene summary

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

Chromosome

14 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

35747839 - 35786699

Ensembl

ENSG00000100902 (version 73.37)

Entrez gene

5687

UniProt

P60900 (UniProt - Evidence at protein level)

neXtProt

NX_P60900

Antibodypedia

PSMA6 antibodies
 

PROTEIN VIEW

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PSMA6-001
 
PSMA6-002
 
PSMA6-003
 
PSMA6-004
 
PSMA6-006
 
PSMA6-009
 
PSMA6-010
 
PSMA6-012
 
PSMA6-013
 
PSMA6-014
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMA6-001 ENSP00000261479
ENST00000261479
P60900
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Show » Show » 246 27.4 No 0
PSMA6-002 ENSP00000444844
ENST00000540871
B4DXJ9
Show all »
Show » 227 25.3 No 0
PSMA6-003 ENSP00000451958
ENST00000554541
G3V4S5
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Show » 41 4.6 No 0
PSMA6-004 ENSP00000452566
ENST00000555764
B4DQR4
Show all »
Show » 167 18.8 No 0
PSMA6-006 ENSP00000450844
ENST00000553688
G3V2S7
Show all »
Show » 67 7.6 No 0
PSMA6-009 ENSP00000451254
ENST00000554961
G3V3I1
Show all »
Show » 148 16.6 No 0
PSMA6-010 ENSP00000452603
ENST00000553809
G3V5Z7
Show all »
Show » Show » 252 28.1 No 0
PSMA6-012 ENSP00000451171
ENST00000556221
Show » 85 9.2 No 0
PSMA6-013 ENSP00000450528
ENST00000556506
G3V295
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Show » 203 22.8 No 0
PSMA6-014 ENSP00000451432
ENST00000554620
G3V3U4
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Show » 107 11.6 No 0