MMP9

GENERAL INFORMATION

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Gene name

MMP9

Gene description

Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (bone marrow, lymph node)
GTEx:Tissue enriched (spleen)

Protein evidence

Evidence at protein level

Protein localization

Selective nuclear and cytoplasmic expression in a subset of hematopoietic cells, spleen and peripheral leukocytes.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 6 antibodies.
HPA001238 , HPA063909 , CAB000348 , CAB068199 , CAB068200 , CAB068201
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (bone marrow, lymph node)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (spleen)

Organ

Expression



GENE INFORMATION

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Gene name

MMP9 (HGNC Symbol)

Synonyms

CLG4B

Description

Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q13.12

Chromosome location (bp)

46008908 - 46016561

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100985 (version 78.38)

Entrez gene

4318

UniProt

P14780 (UniProt - Evidence at protein level)

neXtProt

NX_P14780

Antibodypedia

MMP9 antibodies


PROTEIN BROWSER

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ENST00000372330
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP9-001 ENSP00000361405
ENST00000372330
P14780
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