MMP9

GENE INFORMATION

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Gene name

MMP9 (HGNC Symbol)

Synonyms

CLG4B

Description

matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]

Chromosome

20 (Chromosome progress)

Cytoband

q13.12

Chromosome location (bp)

44637547 - 44645200

Ensembl

ENSG00000100985 (version 73.37)

Entrez gene

4318

UniProt

P14780 (UniProt - Evidence at protein level)

neXtProt

NX_P14780

Antibodypedia

MMP9 antibodies
 

PROTEIN VIEW

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MMP9-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP9-001 ENSP00000361405
ENST00000372330
P14780
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