CD40

GENE INFORMATION

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Gene name

CD40 (HGNC Symbol)

Synonyms

Bp50, p50, TNFRSF5

Description

CD40 molecule, TNF receptor superfamily member 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q13.12

Chromosome location (bp)

44746911 - 44758502

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101017 (version 75.37)

Entrez gene

958

UniProt

P25942 (UniProt - Evidence at protein level)

neXtProt

NX_P25942

Antibodypedia

CD40 antibodies
 

PROTEIN VIEW

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CD40-001
 
CD40-002
 
CD40-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD40-001 ENSP00000361359
ENST00000372285
P25942
Show all »
Show » Show » 277 30.6 Yes 1
CD40-002 ENSP00000361350
ENST00000372276
P25942
Show all »
Show » Show » 203 22.3 Yes 0
CD40-006 ENSP00000434825
ENST00000466205
Q09LL4
Show all »
Show » Show » 159 17.8 Yes 0