HNF4A

GENE INFORMATION

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Gene name

HNF4A (HGNC Symbol)

Synonyms

HNF4, MODY, MODY1, NR2A1, TCF14

Description

hepatocyte nuclear factor 4, alpha (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]

Chromosome

20 (Chromosome progress)

Cytoband

q13.12

Chromosome location (bp)

42984340 - 43060030

Ensembl

ENSG00000101076 (version 73.37)

Entrez gene

3172

UniProt

P41235 (UniProt - Evidence at protein level)

neXtProt

NX_P41235

Antibodypedia

HNF4A antibodies
 

PROTEIN VIEW

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HNF4A-001
 
HNF4A-002
 
HNF4A-003
 
HNF4A-004
 
HNF4A-201
 
HNF4A-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HNF4A-001 ENSP00000315180
ENST00000316673
P41235
Show all »
Show » Show » 452 50.1 No 0
HNF4A-002 ENSP00000312987
ENST00000316099
P41235
Show all »
Show » Show » 474 52.8 No 0
HNF4A-003 ENSP00000362011
ENST00000372920
F8WBS7
Show all »
Show » 107 12 No 0
HNF4A-004 ENSP00000410911
ENST00000443598
P41235
Show all »
Show » Show » 417 46.6 No 0
HNF4A-201 ENSP00000412111
ENST00000415691
P41235
Show all »
Show » Show » 464 51.6 No 0
HNF4A-202 ENSP00000396216
ENST00000457232
P41235
Show all »
Show » Show » 442 49 No 0