NFATC2

GENERAL INFORMATION

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Gene name

NFATC2

Gene description

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

Protein class

Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

High cytoplasmic expression in lymphoid tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA008789 , HPA024369 , CAB018567
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

NFATC2 (HGNC Symbol)

Synonyms

NF-ATP, NFAT1, NFATp

Description

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (HGNC Symbol)

Entrez gene summary

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]

Chromosome

20

Cytoband

q13.2

Chromosome location (bp)

51386957 - 51562831

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101096 (version 78.38)

Entrez gene

4773

UniProt

Q13469 (UniProt - Evidence at protein level)

neXtProt

NX_Q13469

Antibodypedia

NFATC2 antibodies


PROTEIN BROWSER

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ENST00000371564
 
ENST00000396009
 
ENST00000414705
 
ENST00000609507
 
ENST00000609943
 
ENST00000610033
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NFATC2-001 ENSP00000360619
ENST00000371564
Q13469
Show all »
Show » Show » 921 99.8 No 0
NFATC2-002 ENSP00000379330
ENST00000396009
Q13469
Show all »
Show » Show » 925 100.1 No 0
NFATC2-004 ENSP00000396471
ENST00000414705
Q13469
Show all »
Show » Show » 901 97.7 No 0
NFATC2-005 ENSP00000477370
ENST00000609943
Q13469
Show all »
Show » Show » 905 98.1 No 0
NFATC2-006 ENSP00000477342
ENST00000609507
Q13469
Show all »
Show » Show » 702 76.7 No 0
NFATC2-007 ENSP00000477142
ENST00000610033
Q13469
Show all »
Show » Show » 702 76.7 No 0