STK4

GENE INFORMATION

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Gene name

STK4 (HGNC Symbol)

Synonyms

KRS2, MST1, YSK3

Description

serine/threonine kinase 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]

Chromosome

20 (Chromosome progress)

Cytoband

q13.12

Chromosome location (bp)

43595115 - 43708600

Ensembl

ENSG00000101109 (version 73.37)

Entrez gene

6789

UniProt

Q13043 (UniProt - Evidence at protein level)

neXtProt

NX_Q13043

Antibodypedia

STK4 antibodies
 

PROTEIN VIEW

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STK4-003
 
STK4-006
 
STK4-201
 
STK4-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STK4-003 ENSP00000361892
ENST00000372806
Q13043
Show all »
Show » Show » 487 55.6 No 0
STK4-006 ENSP00000361887
ENST00000372801
Q13043
Show all »
Show » Show » 462 52.3 No 0
STK4-201 ENSP00000379957
ENST00000396731
Q13043
Show all »
Show » Show » 462 52.3 No 0
STK4-202 ENSP00000443514
ENST00000499879
F5H5B4
Show all »
Show » Show » 432 49.5 No 0