PSMA7

GENE INFORMATION

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Gene name

PSMA7 (HGNC Symbol)

Synonyms

C6, HSPC, RC6-1, XAPC7

Description

proteasome (prosome, macropain) subunit, alpha type, 7 (HGNC Symbol)

Entrez gene summary

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]

Chromosome

20 (Chromosome progress)

Cytoband

q13.33

Chromosome location (bp)

60711791 - 60718496

Ensembl

ENSG00000101182 (version 73.37)

Entrez gene

5688

UniProt

O14818 (UniProt - Evidence at protein level)

neXtProt

NX_O14818

Antibodypedia

PSMA7 antibodies
 

PROTEIN VIEW

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PSMA7-001
 
PSMA7-002
 
PSMA7-005
 
PSMA7-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMA7-001 ENSP00000359910
ENST00000370873
O14818
Show all »
Show » Show » 248 27.9 No 0
PSMA7-002 ENSP00000359898
ENST00000370861
O14818
Show all »
Show » Show » 178 20.2 No 0
PSMA7-005 ENSP00000359895
ENST00000370858
O14818
Show all »
Show » Show » 149 16.1 No 0
PSMA7-006 ENSP00000397047
ENST00000442551
Show » 187 21.1 No 0