CHRNA4

GENERAL INFORMATION

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Gene name

CHRNA4

Gene description

Cholinergic receptor, nicotinic, alpha 4 (neuronal)

Protein class

Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (cerebral cortex, liver, spleen)
GTEx:Tissue enhanced (liver)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression at low levels in liver, kidney, spleen and cerebral cortex. RNA-based expert annotation could not be performed.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
CAB034064
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (cerebral cortex, liver, spleen)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (liver)

Organ

Expression



GENE INFORMATION

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Gene name

CHRNA4 (HGNC Symbol)

Synonyms

BFNC, EBN, EBN1

Description

Cholinergic receptor, nicotinic, alpha 4 (neuronal) (HGNC Symbol)

Entrez gene summary

This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Chromosome

20

Cytoband

q13.33

Chromosome location (bp)

63343310 - 63378401

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101204 (version 78.38)

Entrez gene

1137

UniProt

P43681 (UniProt - Evidence at protein level)

neXtProt

NX_P43681

Antibodypedia

CHRNA4 antibodies


PROTEIN BROWSER

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ENST00000370263
 
ENST00000615287
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHRNA4-001 ENSP00000359285
ENST00000370263
P43681
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Show » Show » 627 70 Yes 4
CHRNA4-201 ENSP00000483388
ENST00000615287
P43681
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Show » Show » 556 61 No 4