CHRNA4

GENE INFORMATION

? »

Gene name

CHRNA4 (HGNC Symbol)

Synonyms

BFNC, EBN, EBN1

Description

cholinergic receptor, nicotinic, alpha 4 (neuronal) (HGNC Symbol)

Entrez gene summary

This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Chromosome

20 (Chromosome progress)

Cytoband

q13.33

Chromosome location (bp)

61975420 - 62009753

Ensembl

ENSG00000101204 (version 73.37)

Entrez gene

1137

UniProt

P43681 (UniProt - Evidence at protein level)

neXtProt

NX_P43681

Antibodypedia

CHRNA4 antibodies
 

PROTEIN VIEW

? »
 
 
 
CHRNA4-001
 
CHRNA4-007
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHRNA4-001 ENSP00000359285
ENST00000370263
P43681
Show all »
Show » Show » 627 70 Yes 4
CHRNA4-007 ENSP00000429513
ENST00000498043
Show » 137 16.1 No 0