CDS2

GENE INFORMATION

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Gene name

CDS2

Synonyms

Description

CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 (HGNC Symbol)

Entrez gene summary

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]

Chromosome

20 (Chromosome progress)

Cytoband

p12.3

Chromosome location (bp)

5107432 - 5178533

Ensembl

ENSG00000101290 (version 73.37)

Entrez gene

8760

UniProt

O95674 (UniProt - Evidence at protein level)

neXtProt

NX_O95674

Antibodypedia

CDS2 antibodies
 

PROTEIN VIEW

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CDS2-002
 
CDS2-004
 
CDS2-201
 
CDS2-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDS2-002 ENSP00000403205
ENST00000450570
O95674
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Show » Show » 250 29.9 No 7
CDS2-004 ENSP00000419879
ENST00000460006
O95674
Show all »
Show » Show » 445 51.4 No 9
CDS2-201 ENSP00000368352
ENST00000379062
E7EQ83
Show all »
Show » Show » 325 37.8 No 7
CDS2-202 ENSP00000440555
ENST00000535100
F6VWC5
Show all »
Show » Show » 215 24.6 No 5