HM13

GENE INFORMATION

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Gene name

HM13 (HGNC Symbol)

Synonyms

dJ324O17.1, H13, IMP1, IMPAS, PSENL3, PSL3, SPP, SPPL1

Description

histocompatibility (minor) 13 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

20 (Chromosome progress)

Cytoband

q11.21

Chromosome location (bp)

30102231 - 30157370

Ensembl

ENSG00000101294 (version 73.37)

Entrez gene

81502

UniProt

Q8TCT9 (UniProt - Evidence at protein level)

neXtProt

NX_Q8TCT9

Antibodypedia

HM13 antibodies
 

PROTEIN VIEW

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HM13-009
 
HM13-011
 
HM13-012
 
HM13-014
 
HM13-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HM13-009 ENSP00000335294
ENST00000335574
Q8TCT9
Show all »
Show » Show » 394 43.4 No 9
HM13-011 ENSP00000343032
ENST00000340852
Q8TCT9
Show all »
Show » Show » 377 41.5 No 9
HM13-012 ENSP00000381237
ENST00000398174
Q8TCT9
Show all »
Show » Show » 426 46.8 No 9
HM13-014 ENSP00000341347
ENST00000344042
Q8TCT9
Show all »
Show » Show » 272 30.2 No 6
HM13-201 ENSP00000365296
ENST00000376127
Q8TCT9
Show all »
Show » Show » 335 36.8 No 7