PAK7

GENE INFORMATION

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Gene name

PAK7 (HGNC Symbol)

Synonyms

KIAA1264, PAK5

Description

p21 protein (Cdc42/Rac)-activated kinase 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Chromosome

20 (Chromosome progress)

Cytoband

p12.2

Chromosome location (bp)

9518036 - 9819689

Ensembl

ENSG00000101349 (version 73.37)

Entrez gene

57144

UniProt

Q9P286 (UniProt - Evidence at protein level)

neXtProt

NX_Q9P286

Antibodypedia

PAK7 antibodies
 

PROTEIN VIEW

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PAK7-001
 
PAK7-002
 
PAK7-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PAK7-001 ENSP00000367686
ENST00000378429
Q9P286
Show all »
Show » Show » 719 80.7 No 0
PAK7-002 ENSP00000322957
ENST00000353224
Q9P286
Show all »
Show » Show » 719 80.7 No 0
PAK7-003 ENSP00000367679
ENST00000378423
Q9P286
Show all »
Show » Show » 719 80.7 No 0