E2F1

GENE INFORMATION

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Gene name

E2F1 (HGNC Symbol)

Synonyms

RBBP3, RBP3

Description

E2F transcription factor 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]

Chromosome

20 (Chromosome progress)

Cytoband

q11.22

Chromosome location (bp)

32263489 - 32274210

Ensembl

ENSG00000101412 (version 73.37)

Entrez gene

1869

UniProt

Q01094 (UniProt - Evidence at protein level)

neXtProt

NX_Q01094

Antibodypedia

E2F1 antibodies
 

PROTEIN VIEW

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E2F1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

E2F1-001 ENSP00000345571
ENST00000343380
Q01094
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